This book is composed by the papers written in English and accepted for presentation and discussion at The 2023 International Conference on Information Technology & Systems (ICITS'23), held at Universidad Nacional de San Antonio Abad del Cusco, in Cusco, Peru, between the 24th and the 26th of April 2023.  ICIST is a global forum for researchers and practitioners to present and discuss recent findings and innovations, current trends, professional experiences and challenges of modern information technology and systems research, together with their technological development and applications.  The main topics covered are: information and knowledge management; organizational models and information systems; software and systems modelling; software systems, architectures, applications and tools; multimedia systems and applications; computer networks, mobility and pervasive systems; intelligent and decision support systems; big dataanalytics and applications; human-computer interaction; ethics, computers & security; health informatics; information technologies in education, and Media, Applied Technology and Communication.